Grootenhuis MA, de Boone J, van der Kooi AJ. There’s some evidence that treatment with angiotensin converting enzyme (ACE) inhibitors and beta blockers can slow the course of cardiac muscle deterioration in BMD if the medications are started as soon as abnormalities on an echocardiogram (imaging of the heart) appear, but before symptoms occur. Heart muscle also is commonly affected, making cardiac problems a prominent feature of the disease. Becker muscular dystrophy (BMD) is a genetic condition that leads to progressive muscle wasting due to a mutation in the gene that makes a muscle-supporting protein called dystrophin. BMD patients that present dysphagia (difficulty with swallowing) should be referred to a speech and language therapist for swallowing assessment. 9:53-63. [22]. Inherited neuromuscular disorders: Pathway to diagnosis. The goal of treatment is to keep muscles as strong as possible to allow a child to function independently. Some patients may need placement of a feeding tube. Treatment. [Medline]. [Full Text]. If a learning disability is diagnosed, educational and psychological interventions can begin right away. [Medline]. 1955. As muscle deteriorates, a person with muscular dystrophy often develops fixations of the joints, known as contractures. ike Duchenne MD, Becker MD mostly affects boys. There are two main types of muscular dystrophy. Risk of fracture in patients with muscular dystrophies. Access and mobility concerns in the community invariably touch upon the adjustment issues faced by individuals with a progressive disability. 2011 Nov 15. 2015. Cognitive and Psychological Profile of Males With Becker Muscular Dystrophy. After walking ability is lost - wheelchairs and other aids. It has been shown that prednisone therapy can be helpful for patients diagnosed with BMD as well.2 However, little is known about the effect of the benefits of glucocorticosteroid (a class of corticosteroid) for BMD patients. Currently there is no known cure for Becker muscular dystrophy. Becker muscular dystrophy (DIS-trah-fee), or BMD, is a genetic disease affecting different groups of muscles in the body. Medications that lessen the workload on the heart are sometimes prescribed for BMD. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. How is Becker muscular dystrophy treated in a child? [Medline]. 4(4):349-58. How is Becker Muscular Dystrophy treated? It primarily affects males. Other extremely rare forms of muscular dystrophy can affect both girls and boys. Dis Markers. Homeopathy Treatment for Muscular Dystrophy The symptoms and weaknesses of the muscular dystrophy can be … A doctor may prescribe steroid medications to help individuals remain able to walk for as long as possible. The clinical course of Becker muscular dystrophy is variable. [Medline]. Becker muscular dystrophy usually affects boys and men. Inactivity, such as bed rest can make the muscle disease worse. Young HK, Barton BA, Waisbren S, et al. Two families of benign sex-linked recessive muscular dystrophy. Becker muscular dystrophy … The clinical course of Becker muscular dystrophy is variable. Preservation of the C-terminus of dystrophin molecule in the skeletal muscle from Becker muscular dystrophy. New treatment for common form of muscular dystrophy shows promise in cells, animals Jun 30, 2020 Researchers developing new 'DNA stitch' to treat muscular dystrophy A genetic disease is one that you are born with and you may have inherited from your family. Yoga for muscular dystrophy – an essential addition to any Natural treatment for muscular dystrophy. Duchenne and Becker muscular dystrophy in adolescents: current perspectives. Ankle-foot orthoses are sometimes prescribed for night wear to keep feet from pointing downward and keep the Achilles tendon stretched. There is no cure for BMD, and treatment is symptomatic. Duchenne and Becker’s muscular dystrophy typically cause the following symptoms: Loss of muscle mass, which progressively gets worse with age. Simultaneous mutation scanning for gross deletions, duplications and point mutations in the DMD gene. The impact of BMD can be significantly minimized by keeping the body as flexible, upright, and mobile as possible. 2005 May 10. 2011 Nov 3. [Medline]. Educational objectives include teaching the patient techniques for energy conservation, joint protection, and the prevention of overuse fatigue. Eur J Hum Genet. Clinical-molecular correlation in 104 mild X-linked muscular dystrophy patients: characterization of sub-clinical phenotypes. Another form of muscular dystrophy caused by dystrophin deficiency is the Becker type. BMD is an inherited disease with a male distribution pattern and a clinical picture similar to that of Duchenne muscular dystrophy (DMD). The Muscular Dystrophy Association (MDA) is a qualified 501(c)(3) tax-exempt organization. Mol Ther. The academy suggests that carriers should undergo a complete cardiac evaluation in late adolescence or early adulthood, or sooner if symptoms occur, and should be evaluated frequently. Stephen Kishner, MD, MHA Professor of Clinical Medicine, Physical Medicine and Rehabilitation Residency Program Director, Louisiana State University School of Medicine in New Orleans Becker muscular dystrophy is less severe than Duchenne muscular dystrophy. But treatment can help prevent or reduce problems in the joints and spine to allow people with muscular dystrophy to remain mobile as long as possible. Please confirm that you would like to log out of Medscape. Becker Muscular Dystrophy Treatment . All material on this website is protected by copyright, Copyright © 1994-2021 by WebMD LLC. [Medline]. It will also depend on how severe the condition is. [Full Text]. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. It's important that the surgical team know about that a patient has BMD so that complications can be avoided or quickly treated. Duan D. Myodys, a full-length dystrophin plasmid vector for Duchenne and Becker muscular dystrophy gene therapy. Becker muscular dystrophy (BMD) has a similar presentation to DMD but a relatively milder clinical course. Becker muscular dystrophy (BMD) has onset usually in childhood, frequently by 11 years. Becker muscular dystrophy. Pediatr Pulmonol. 2007. 2015 Mar 1. LGMD2I presenting with a characteristic Duchenne or Becker muscular dystrophy phenotype. BMD causes muscle cells to die, and results in the muscle becoming weak, small, and deformed. If you have muscular dystrophy, the primary symptom is muscle weakness. Treatment for muscular dystrophy. 1 A defining feature of BMD is a high degree of variability in symptoms— including onset, severity, and cor- The aim of gene therapy is to deliver DNA encoding dystrophin or other therapeutic genes, such as utrophin, to muscle. Inactivity (such as bed rest) or sitting down for too long can worsen the muscle disease. To see a presentation by a pulmonary medicine specialist, see the August 2012 video Lung Health in Neuromuscular Disease. Arch Psychiatr Nervenkr Z Gesamte Neurol Psychiatr. Glucocorticoid treatment should be stopped progressively to avoid adverse reactions. Because no cure exists for BMD, treatment is focused on controlling a patient's symptoms. Trials of new therapies are ongoing. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Pouwels S, de Boer A, Leufkens HG, Weber WE, Cooper C, van Onzenoort HA, et al. Francisco Talavera, PharmD, PhD Adjunct Assistant Professor, University of Nebraska Medical Center College of Pharmacy; Editor-in-Chief, Medscape Drug ReferenceDisclosure: Received salary from Medscape for employment. The primary goals of physical therapy are to allow greater motion in the joints and to prevent contractures and scoliosis (spinal curvature). Rarely cardiomyopathy might be the presenting feature. To view an August 2012 video presentation on this topic, see Functional Treatment Considerations: Orthotics. A tendon release procedure, also called heel cord surgery, can treat ankle and other contractures while a person is still walking. Medications belonging to a group known as corticosteroids – or glucocorticoids –  have been found effective in slowing the course of DMD. It is important that a health professional be available to help coordinate care for anyone with muscular dystrophy. Emery AE, Skinner R. Clinical studies in benign (Becker type) X-linked muscular dystrophy. Treatments … The onset of this condition is slower and the symptoms start later in childhood. BMD is caused by dys … Becker and Kiener initially described Becker muscular dystrophy (BMD) in 1955. BMD is similar to Duchenne muscular dystrophy (DMD), except that it develops … Duchenne muscular dystrophy (DMD) is associated with the most severe clinical symptoms. 1259041-overview Some men need a wheelchair, while others may only need walking aids such as canes or braces. Swallowing-related complications, from difficulties with mastication to problems in the pharyngeal phases, may arise with progressive weakness of the swallow mechanism. It’s important that a physical therapist demonstrate the correct way to do range-of-motion exercises. 1-5. Orthopedic appliances such as braces and wheelchairs may improve mobility and self-care. Much of the pioneering research into a treatment for Duchenne muscular dystrophy may also benefit those with Becker muscular dystrophy. 5:31. It usually appears between the ages of 2 and 16 but can appear up to the age of 25. It is vital that a person with BMD stay in shape and continue to use their muscles. What are the treatments for Becker muscular dystrophy? Recurrent aspiration pneumonias from progressive dysphagia may eventually cause mortality in BMD. Becker dystrophy has later onset and causes milder symptoms. ©2021, Muscular Dystrophy Association Inc. All rights reserved. [Full Text]. Early research on genetic treatments for the various forms of muscular dystrophy involved using actual DNA to restore missing proteins. Other aspects of Duchenne and Becker muscular dystrophy are reviewed separately. The investigators reported that BMD patients did not differ from those with DMD with regard to the rate of aspiration or scores on the penetration-aspiration scale or total videofluorographic dysphagia scale. Curr Opin Mol Ther. People with BMD may have unexpected adverse reactions to certain types of anesthesia. 2008 Feb. 18(2):100-6. Arahata K, Beggs AH, Honda H, et al. Terms of Use | State Fundraising Notices. Early interventions may focus on stretching tight muscles (which may initially be the only therapy goal). [Medline]. J Child Neurol. Scooters and wheelchairs are especially valuable when covering long distances. BMD is caused by dys … Current and Emerging Therapies in Becker Muscular Dystrophy (BMD) Acta Myol. However, the condition is closely related to Duchenne muscular dystrophy. A combination of immobility and weak abdominal muscles can lead to severe constipation, so the diet should be high in fluid and fiber, with fresh fruits and vegetables dominant. [Full Text]. As the patient's weakness progresses, appropriate equipment and … As different types of MD can cause quite specific problems, the treatment you receive will be tailored to your needs. The disease is found mostly in boys. This can include physical therapy. Becker muscular dystrophy This type of muscular dystrophy also more commonly affects boys. Heel cord release is a commonly performed joint contracture procedure. There is no known cure for BMD, or treatment to stop the muscles from weakening. 2013 Aug 15. Holloway SM, Wilcox DE, Wilcox A, et al. Segura LG, Lorenz JD, Weingarten TN, Scavonetto F, Bojanic K, Selcen D, et al. Am J Hum Genet. Monitoring/treatment of complications. In some people with BMD, particularly as they age, breathing muscles can weaken, resulting in less-than-optimal breathing, particularly during sleep. [Medline]. Progressive scoliosis and contracture formation may require surgical intervention. Educational institutions, from public schools to community colleges and universities, may have resources that can be utilized. Elizabeth A Moberg-Wolff, MD Medical Director, Pediatric Rehabilitation Medicine Associates 2017 Mar 13. Kids usually get diagnosed with the condition after age 7. As your symptoms develop, the healthcare professionals treating you will advise on the options. There is not a cure for Becker muscular dystrophy at present. muscular dystrophy (DMD), which is caused by different mutations in the same gene. Activity is encouraged. Muscular dystrophy treatment has improved in recent years and there is a great deal of research into future treatments and possible cures. Some people with Becker MD begin using a wheelchair in their twenties. If you log out, you will be required to enter your username and password the next time you visit. Like Duchenne MD, Becker MD mostly affects boys. Neuromuscul Disord. Data for or against the use of corticosteroids in BMD are lacking. [28, 29]. Subspecialty consultations depend on the patient's specific needs as related to the disorder. Generally, walking difficulties begin after the age of 16. Becker MD does not affect muscles of the bowel and bladder or sexual function. Symptoms of Becker MD usually begin in childhood, but they're often relatively mild at this point. There is no cure for muscular dystrophy and no way to stop it from getting worse. Coughing muscles also can become weak, allowing mucus to build up in the respiratory tract, which can lead to obstruction and infection. This disease is caused by a mutation in the gene that encodes a protein called dystrophin. Zhang H, Zhu Y, Sun Y, et al. 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